The mixture of endocrine chemicals causes a "cocktail effect" that generates malformations
Endocrine "switch" substances, which do not cause damage to the organism in small individual doses, could constitute a dangerous cocktail in a joint manner. Its exposure can cause, among others, malformations in the sexual organs. In this research work, developed by researchers from the National Food Institute of the Technical University of Denmark (Danish Technical University), the effects of the risk assessment are exposed to these Chemicals, taking into account their "cocktail effect".
Sync/AG | 18 February 2018 1:44 It is known that many young men have fewer sperm numbers and that more and more children are born with malformations in their sexual organs. In Denmark, less than five percent of Danish children are born with Hipospadia, a disease in which the opening of the urethra is located in the lower part of the penis.
For a long time, it is suspected that substances that disturb hormonal balance during fetal development may also cause birth defects.
In fact, several animal tests have shown that endocrine-disrupting chemicals, which affect the hormone testosterone in males, can cause these types of malformations in rats.
This is linked to the fact that exposure to these chemicals can have negative effects on the endocrine system, even though exposure to each of these substances individually has no effect. "We can now document that this is what happens in reality," says Ulla Hass, a scientist at the National Institute of Food at the Technical University of Denmark.
Important "cocktail effect" the National Institute of Food of the Technical University of Denmark has conducted exposure studies of the pregnant rats to a cocktail of three chemicals that inhibit the effects of testosterone on the male: Flutamide drug, and Vinclozolín and procymidone pesticides.
The three substances were administered in harmless doses on an individual basis. However, the joint exhibition of the three meetings has demonstrated the production of significant "cocktail effects". Among others, male rats developed female traits such as retracted nipples and external sex organs with severe malformations. For example, sixty percent of the rats were born with Hipospadia.
Undervalued risk today, the risk assessment of these chemicals and the setting of reference values are made with respect to one substance at a time, even though people are exposed to many different chemicals each day.
"Our studies show that joint exposure to various endocrine" switchers "in small doses may increase the frequency of malformations such as Hipospadia, even though the same doses are harmless individually. It is not enough to establish a reference value if one is studying a single substance at a time, "concludes Sofie Christiansen, a researcher at the National Institute of Food at the Technical University of Denmark.
"In order not to underestimate the risk of chemicals in humans it is important to include the exposure of two or more chemicals in the risk assessment and to establish a level of adequate protection for the consumer. You should also consider the cocktail effects and how a chemical can interact with other chemicals, "adds Ulla Hass.
Sync/AG | 18 February 2018 1:44 It is known that many young men have fewer sperm numbers and that more and more children are born with malformations in their sexual organs. In Denmark, less than five percent of Danish children are born with Hipospadia, a disease in which the opening of the urethra is located in the lower part of the penis.
For a long time, it is suspected that substances that disturb hormonal balance during fetal development may also cause birth defects.
In fact, several animal tests have shown that endocrine-disrupting chemicals, which affect the hormone testosterone in males, can cause these types of malformations in rats.
This is linked to the fact that exposure to these chemicals can have negative effects on the endocrine system, even though exposure to each of these substances individually has no effect. "We can now document that this is what happens in reality," says Ulla Hass, a scientist at the National Institute of Food at the Technical University of Denmark.
Important "cocktail effect" the National Institute of Food of the Technical University of Denmark has conducted exposure studies of the pregnant rats to a cocktail of three chemicals that inhibit the effects of testosterone on the male: Flutamide drug, and Vinclozolín and procymidone pesticides.
The three substances were administered in harmless doses on an individual basis. However, the joint exhibition of the three meetings has demonstrated the production of significant "cocktail effects". Among others, male rats developed female traits such as retracted nipples and external sex organs with severe malformations. For example, sixty percent of the rats were born with Hipospadia.
Undervalued risk today, the risk assessment of these chemicals and the setting of reference values are made with respect to one substance at a time, even though people are exposed to many different chemicals each day.
"Our studies show that joint exposure to various endocrine" switchers "in small doses may increase the frequency of malformations such as Hipospadia, even though the same doses are harmless individually. It is not enough to establish a reference value if one is studying a single substance at a time, "concludes Sofie Christiansen, a researcher at the National Institute of Food at the Technical University of Denmark.
"In order not to underestimate the risk of chemicals in humans it is important to include the exposure of two or more chemicals in the risk assessment and to establish a level of adequate protection for the consumer. You should also consider the cocktail effects and how a chemical can interact with other chemicals, "adds Ulla Hass.
Comentarios
Publicar un comentario